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1

Efficacy of ajoene in the treatment of tinea pedis: A double-blind and comparative study with terbinafine

Eliades Ledezma, Katiuska Marcano, Alicia Jorquera, Leonardo De Sousa, Maria Padilla, Mireya Pulgar, Rafael Apitz-Castro

Journal:

Journal of the American Academy of Dermatology

Year:

2000

Language:

english

File:

PDF, 148 KB

english, 2000

2

The chemistry of alkyl thiosulfate esters. 8. (E,Z)-Ajoene: a potent antithrombotic agent from garlic

Block, Eric, Ahmad, Saleem, Jain, Mahendra K., Crecely, Roger W., Apitz-Castro, Rafael, Cruz, Maria R.

Journal:

Journal of the American Chemical Society

Year:

1984

Language:

english

File:

PDF, 294 KB

english, 1984

3

Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene

Katsuhito Teranishi, Rafael Apitz-Castro, Simon C. Robson, Egidio Romano, David K. C. Cooper

Journal:

Xenotransplantation

Year:

2003

Language:

english

File:

PDF, 261 KB

english, 2003

4

Fabry disease in a Venezuelan family

R Apitz-Castro, F López, H Resnik-Wolf, I Sarban, EJ Holtzman

Journal:

Acta Paediatrica

Year:

2002

Language:

english

File:

PDF, 160 KB

english, 2002

5

Plasma membrane phosphorylation by endogenous phosphate donors in human blood platelets Selectivity of the action of dibutyryl cyclic AMP

Rafael Apitz-Castro, Edgar Ramírez, Rhaiza Maingon, Alicia de Murciano, Alida Ribbi

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1976

Language:

english

File:

PDF, 659 KB

english, 1976

6

Ajoene, the antiplatelet compound derived from garlic, specifically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity

F. Rendu, D. Daveloose, J.C. Debouzy, N. Bourdeau, S. Levy-Toledano, M.K. Jain, R. Apitz-Castro

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 750 KB

english, 1989

7

Inhibition of phosphatidylcholine biosynthesis and cell proliferation in trypanosomacruzi by ajoene, an antiplatelet compound isolated from garlic

Julio A. Urbina, Edgar Marchan, Keyla Lazardi, Gonzalo Visbal, Rafael Apitz-Castro, Francisco Gil, Tania Aguirre, Marta M. Piras, Romano Piras

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.24 MB

english, 1993

8

Apoptotic and anti-adhesion effect of ajoene, a garlic derived compound, on the murine melanoma B16F10 cells: possible role of caspase-3 and the α4β1 integrin

Eliades Ledezma, Rafael Apitz-Castro, José Cardier

Journal:

Year:

2004

Language:

english

File:

PDF, 232 KB

english, 2004

9

The molecular basis of the antiplatelet action of ajoene: Direct interaction with the fibrinogen receptor

Rafael Apitz-Castro, Eliades Ledezma, Javier Escalante, Mahendra Kumar Jain

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 301 KB

english, 1986

10

The chemistry of alkyl thiosulfinate esters. 9. Antithrombotic organosulfur compounds from garlic: structural, mechanistic, and synthetic studies

Block, Eric., Ahmad, Saleem., Catalfamo, James L., Jain, Mahendra K., Apitz-Castro, Rafael.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 1.50 MB

english, 1986

11

Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets

Rafael Apitz-Castro, Javier Escalante, Roberto Vargas, Mahendra K. Jain

Journal:

Thrombosis Research

Year:

1986

Language:

english

File:

PDF, 732 KB

english, 1986

12

Evidence for direct coupling of primary agonist-receptor interaction to the exposure of functional IIb–IIIa complexes in human blood platelets. Results from studies with the antiplatelet compound ajoene

Rafael Apitz-Castro, Mahendra Kumar Jain, Fulvia Bartoli, Eliades Ledezma, Marie-Cristine Ruiz, Rafael Salas

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1991

Language:

english

File:

PDF, 864 KB

english, 1991

13

Effect of ajoene on dimorphism of Paracoccidioides brasiliensis

San-Blas, G., Mariño, L., San-Blas, F., Apitz-Castro, R.

Journal:

Medical Mycology

Year:

1993

Language:

english

File:

PDF, 1.61 MB

english, 1993

14

ChemInform Abstract: THE CHEMISTRY OF ALKYL THIOSULFATE ESTERS. 8. (E,Z)-AJOENE: A POTENT ANTITHROMBOTIC AGENT FROM GARLIC

BLOCK, E., AHMAD, S., JAIN, M. K., CRECELY, R. W., APITZ-CASTRO, R., CRUZ, M. R.

Journal:

Chemischer Informationsdienst

Year:

1985

File:

PDF, 142 KB

1985

15

Wirkung des Knoblauchs – Wahrheit und Dichtung. Molekulare Grundlagen des überlieferten Brauchtums

Mahendra Kumar Jain, Carla Scanzello, Rafael Apitz-Castro

Journal:

Chemie in unserer Zeit

Year:

1988

Language:

german

File:

PDF, 3.10 MB

german, 1988

16

Plasma total homocysteine quantification: an improvement of the classical high-performance liquid chromatographic method with fluorescence detection of the thiol-SBD derivatives

Alberto J Garcia, Rafael Apitz-Castro

Journal:

Journal of Chromatography B

Year:

2002

Language:

english

File:

PDF, 194 KB

english, 2002

17

Pig peripheral blood mononuclear cells are directly associated with the thrombotic microangiopathy that complicates the induction of chimerism in pig-to-baboon xenotransplantation

Lorenzo Benatuil, Ana Zita Fernandez, Rafael Apitz-Castro, Egidio Romano

Journal:

Xenotransplantation

Year:

2002

Language:

english

File:

PDF, 377 KB

english, 2002

18

Ajoene inhibits the activation of human endothelial cells induced by porcine cells: implications for xenotransplantation

Lorenzo Benatuil, Rafael Apitz-Castro, Egidio Romano

Journal:

Xenotransplantation

Year:

2003

Language:

english

File:

PDF, 401 KB

english, 2003

19

Interaction of antiaggregant molecule ajoene with membranes

J.-C. Debouzy, J.-M. Neumann, M. Hervé, D. Daveloose, J. Viret, R. Apitz-Castro

Journal:

European Biophysics Journal

Year:

1989

Language:

english

File:

PDF, 505 KB

english, 1989

20

The phospholipase A2from human platelets

Rafael Apitz-Castro, Maria R. Cruz, Manuel Mas, Mahendra K. Jain

Journal:

Inflammation Research

Year:

1981

Language:

english

File:

PDF, 272 KB

english, 1981

21

High Plasma Phospholipase A2 Activity, Inflammation Markers, and LDL Alterations in Obesity With or Without Type 2 Diabetes

Fatima Garces, Flor López, Cladimar Niño, Anazita Fernandez, Luis Chacin, Eva Hurt-Camejo, Germán Camejo, Rafael Apitz-Castro

Journal:

Year:

2010

Language:

english

File:

PDF, 236 KB

english, 2010

22

Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation

Nicola Ferri, Kohei Yokoyama, Martin Sadilek, Rodolfo Paoletti, Rafael Apitz-Castro, Michael H Gelb, Alberto Corsini

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

23

Whole-Blood Thrombin Generation Monitored with a Calibrated Automated Thrombogram-Based Assay

Ninivaggi, M., Apitz-Castro, R., Dargaud, Y., de Laat, B., Hemker, H. C., Lindhout, T.

Journal:

Clinical Chemistry

Year:

2012

Language:

english

File:

PDF, 412 KB

english, 2012

24

Glycoprotein biosynthesis by human normal platelets

Providencia Rodríguez, Olga Bello, Rafael Apitz-Castro

Journal:

Biochemical Medicine and Metabolic Biology

Year:

1987

Language:

english

File:

PDF, 517 KB

english, 1987

25

Galactosylation of endogenous proteins from human platelets

Providencia Rodríguez, Olga Bello, Alfonso Tablante, Rafael Apitz-Castro

Journal:

Biochemical Medicine and Metabolic Biology

Year:

1988

Language:

english

File:

PDF, 686 KB

english, 1988

26

Efecto inhibitorio in vitro de ajoeno sobre aislamientos de Candida recuperados de secreciones vaginales

Sarelie Carrero, Hilda Romero, Rafael Apitz-Castro

Journal:

Revista Iberoamericana de Micología

Year:

2009

File:

PDF, 143 KB

2009

27

Draculin, the anticoagulant factor in vampire bat saliva, is a tight-binding, noncompetitive inhibitor of activated factor X

Ana Z. Fernandez, Alfonso Tablante, Suzette Beguı́n, H.Coenraad Hemker, Rafael Apitz-Castro

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1999

Language:

english

File:

PDF, 277 KB

english, 1999

28

Inmunoanálisis enzimático (ELISA) en la evolución terapéutica de la cromoblastomicosis por Cladophialophora carrionii en el área endémica del Estado Falcón, Venezuela

Lairet Oberto-Perdigón, Hilda Romero, Maigualida Pérez-Blanco, Rafael Apitz-Castro

Journal:

Revista Iberoamericana de Micología

Year:

2005

File:

PDF, 315 KB

2005

29

Ajoene, el principal compuesto activo derivado del ajo (Allium sativum), un nuevo agente antifúngico

Eliades Ledezma, Rafael Apitz-Castro

Journal:

Revista Iberoamericana de Micología

Year:

2006

File:

PDF, 368 KB

2006

30

Actividad antifúngica del ajoeno en la paracoccidioidomicosis experimental en ratones

Marcia L.F. Maluf, Gisele Takahachi, Terezinha I.E. Svidzinski, Patricia Xander, Raphael Apitz-Castro, Ciomar A. Bersani-Amado, Roberto K.N. Cuman

Journal:

Revista Iberoamericana de Micología

Year:

2008

Language:

english

File:

PDF, 309 KB

english, 2008

31

The storage pool deficiency in platelets from humans with the Chédiak-Higashi syndrome: study of six patients

Rafael Apitz-Castro, Maria Rosa Cruz, Eliades Ledezma, Fernando Merino, Pedro Ramirez-Duque, Carol Dangelmeier, Holm Holmsen

Journal:

British Journal of Haematology

Year:

1985

Language:

english

File:

PDF, 823 KB

english, 1985

32

β-Methylcrotonyl-CoA-Carboxylase : Kristallisation und einige physikalische Eigenschaften

Rafael Apitz-Castro, Kurt Rehn, Feodor Lynen

Journal:

Year:

1970

File:

PDF, 1.67 MB

1970

33

Efficacy of ajoene, an organosulphur derived from garlic, in the short-term therapy of tinea pedis

E. Ledezma, L. De Sousa, A. Jorquera, J. Sanchez, A. Lander, E. Rodriguez, M. K. Jain, R. Apitz-Castro

Journal:

Year:

1996

Language:

english

File:

PDF, 540 KB

english, 1996

34

Origin of the latency phase during the action of phospholipase A2 on unmodified phosphatidylcholine vesicles

Rafael Apitz-Castro, Mahendra K. Jain, Gerard H. De Haas

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1982

Language:

english

File:

PDF, 627 KB

english, 1982

35

Interaction of phospholipase A2 and phospholipid bilayers

Mahendra K. Jain, Maarten R. Egmond, Hubertus M. Verheij, Rafael Apitz-Castro, Ruud Dijkman, Gerard H. De Haas

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1982

Language:

english

File:

PDF, 614 KB

english, 1982

36

Dual effect of N-ethylmaleimide and other maleimides on α-glycerophosphate dehydrogenase activity

R. Apitz-Castro, Z. Suarez

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1969

Language:

english

File:

PDF, 173 KB

english, 1969

37

Structural studies on the active center of α-glycerolphosphate dehydrogenase

Rafael Apitz-Castro, Zadila Suarez

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1970

Language:

english

File:

PDF, 393 KB

english, 1970

38

α-glycerolphosphate dehydrogenase: A regulatory enzyme

Zadila Suarez, Rafael Apitz-Castro

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1972

Language:

english

File:

PDF, 214 KB

english, 1972

39

A new catalytic activity of α-glycerolphosphate dehydrogenase: The enzymatic hydrolysis of p-nitrophenyl acetate

Marcelo Alfonzo, Rafael Apitz-Castro

Journal:

Year:

1971

Language:

english

File:

PDF, 240 KB

english, 1971

40

Studies on the mechanism by which inorganic arsenate facilitates the enzymatic reduction of dihydroxy acetone by α-glycerophosphate dehydrogenase

Klaus Jaffé, R. Apitz-Castro

Journal:

Year:

1977

Language:

english

File:

PDF, 278 KB

english, 1977

41

Role of 57–72 loop in the allosteric action of bile salts on pancreatic IB phospholipase A2: Regulation of fat and cholesterol homeostasis

Bao-Zhu Yu, Rafael J. Apitz-Castro, Mahendra K. Jain, Otto G. Berg

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

2007

Language:

english

File:

PDF, 530 KB

english, 2007

42

Trifluoromethyl ketones and methyl fluorophosphonates as inhibitors of group IV and VI phospholipases A2: structure-function studies with vesicle, micelle, and membrane assays

Farideh Ghomashchi, Richard Loo, Jesús Balsinde, Fulvia Bartoli, Rafael Apitz-Castro, James D. Clark, Edward A. Dennis, Michael H. Gelb

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1999

Language:

english

File:

PDF, 286 KB

english, 1999

43

Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule

Ana Z. Fernandez, Alfonso Tablante, Fulvia Bartoli, Suzette Beguin, H.C. Hemker, Rafael Apitz-Castro

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1998

Language:

english

File:

PDF, 329 KB

english, 1998

44

In vitro suppression of HIV-1 replication by ajoene [(e)-(z)-4,5,9-trithiadodeca-1,6,11-triene-9 oxide]

R Walder, Z Kalvatchev, D Garzaro, M Barrios, R Apitz-Castro

Journal:

Biomedicine & Pharmacotherapy

Year:

1997

Language:

english

File:

PDF, 583 KB

english, 1997

45

Selective in vitro protection of SIVagm-induced cytolysis by ajoene, [(E)-(Z)-4,5,9-trithiadodeca-1,6,11-triene-9 oxide]

R Walder, Z Kalvatchev, R Apitz-Castro

Journal:

Biomedicine & Pharmacotherapy

Year:

1998

Language:

english

File:

PDF, 570 KB

english, 1998

46

Isolation of homogeneous phospholipase A2 from human platelets

Rafael J. Apitz-Castro, Manuel A. Mas, María R. Cruz, Mahendra Kumar Jain

Journal:

Biochemical and Biophysical Research Communications

Year:

1979

Language:

english

File:

PDF, 917 KB

english, 1979

47

Metabolic isotopic labelling of plasma membrane glycoproteins from normal, Glanzmann's and Bernard-Soulier platelets

R. Apitz-Castro, V. Michelena, V. Sorribes, P. Rodríguez

Journal:

Thrombosis Research

Year:

1979

Language:

english

File:

PDF, 652 KB

english, 1979

48

Further studies on a phospholipase A2 isolated from human platelet plasma membranes

R. Apitz-Castro, M. Cruz, M. Mas, M.K. Jain

Journal:

Thrombosis Research

Year:

1981

Language:

english

File:

PDF, 495 KB

english, 1981

49

Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reaction and platelet ultrastructure

R. Apitz-Cȧstro, S. Cabrera, M.R. Cruz, E. Ledezma, M.K. Jain

Journal:

Thrombosis Research

Year:

1983

Language:

english

File:

PDF, 1.96 MB

english, 1983

50

Protein and glycoprotein abnormalities in platelets from human Chediak-Higashi Syndrome: Polyacrylamide gel electrophoretic study of platelets from five patients

Eliades Ledezma, Rafael Apitz-Castro

Journal:

Thrombosis Research

Year:

1985

Language:

english

File:

PDF, 631 KB

english, 1985

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